A device having a housing; a cannula projecting fon/vardly from the housing; aconnector useful for attaching thedevice to a fluid source or receptacle; a fluid flow path establishing fluidcommunication between the cannula and the connector; aretraction mechanism biasing the cannula away from its projecting position;and an actuator supported by the housing and configuredto modify the fluid flow path so as to terminate fluid flow through thedevice, seal off the fluid flow path, and release the retractionmechanism to retract the cannula into the housing. The subject device isparticularly preferred for use in the medical field,for example, as part of an infusion set or as a collection device for blood,or other fluids or flowable matter.