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COMPOSITIONS WITH PERMEATION ENHANCERS FOR DRUG DELIVERY
专利权人:
Children's Medical Center Corporation
发明人:
Daniel S. Kohane,Rong Yang
申请号:
US16333368
公开号:
US20200138710A1
申请日:
2017.09.14
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present invention provides compositions and methods for delivery of therapeutic agents across an barrier. The compositions include a therapeutic agent (e.g., antimicrobial agent, antibiotic, or anesthetic agent), a permeation enhancer which increases the flux of the therapeutic agent across the barrier, and a matrix forming agent. The matrix forming agent forms a gel at a suitable gelation temperature and has rheological properties for use in drug delivery, and in some cases, the gelation temperature and rheological properties are not significantly changed from those of the composition without the permeation enhancer. The invention also provides a matrix forming agent and compositions thereof. Such compositions are particularly useful in the treatment of infectious disease (e.g., otitis media). Methods of treatment, methods of delivery, and kits for the compositions described herein are also provided.
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中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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