COMPOSITIONS COMPRISING PRFA*MUTANT LISTERIA AND METHODS OF USE THEREOF

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专利权人:

发明人:

申请号：

EP09751313.9

公开号：

EP2283112B1

申请日:

2009.05.18

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

The invention provides recombinant Listeria that constitutively express Prf A and comprise polynucleotides that encode polypeptides such as tumor or infectious agent antigens, operably linked to a PrfA responsive regulatory agent. Methods of using the Listeria, and compositions thereof, to induce or enhance an immune response and/or in the treatment of disease are provided. Methods of producing the bacteria are also provided.

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