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ИММУНИЗАЦИЯ ВЕКТОРОМ НА ОСНОВЕ ВИРУСА БЕШЕНСТВА, ЭКСПРЕССИРУЮЩИМ ЧУЖЕРОДНЫЙ БЕЛКОВЫЙ АНТИГЕН
专利权人:
ТОМАС ДЖЕФФЕРСОН ЮНИВЕРСИТИ (US)
发明人:
ДИТЦШОЛЬД Бернхард (US),ХУПЕР Дуглас Крэйг (US),ФАБЕР Милош (US)
申请号:
RU2015116904
公开号:
RU2015116904A
申请日:
2013.09.24
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A method for inducing an immune response in an individual, comprising the steps of: (a) obtaining attenuated recombinant rabies virus encoding at least one heterologous protein antigen operably linked to control sequences that control the expression of said foreign antigen into a suitable recipient cell (b) introducing said rabies virus in said individual recipient cell under conditions which allow expression of said one or more protein antigens alien newly, thereby inducing an immune response against said foreign protein antigen, (c) enhancing said immune response against said foreign protein antigen by administering to said individual of said foreign protein antigen contained in the reinforcing composition that does not contain adyuvanta.2. A method according to Claim. 1, wherein the foreign protein antigen is not expressed in recombinant virusa.3 structure. A method according to Claim. 1, wherein the foreign protein antigen comprises antigen.4 prion protein. A method according to Claim. 1, wherein said foreign protein antigen comprises at least one antigen selected from the group consisting of a cancer associated antigens, viral antigens, bacterial antigens and antigens prosteyshih.5. A method according to claim. 4, wherein associated with malignant tumor antigen is selected from the group consisting of AIM-2, AFP, associated with cancer of the urinary protein bladder, associated with mammary carcinoma MAR-binding proteins p90 and p70, associated with mammary protein cancer 3, carcinoembryonic antigen, CA-125 antigen1. Способ индукции иммунного ответа у индивидуума, включающий стадии:(a) получения аттенуированного рекомбинантного вируса бешенства, кодирующего по меньшей мере один чужеродный белковый антиген, функционально связанный с последовательностями контроля, которые контролируют экспрессию указанного чужеродного антигена в подходящей реципиентной клетке(b) введения указанного вируса бешенства в реципиентную клетку указанного индивидуума в условиях, котор
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