Heman CHAO,Wah Yau WONG,Baomin TIAN,Kimberly Jayne GASPAR,Praveen KUMAR
申请号:
US15545549
公开号:
US20180000963A1
申请日:
2016.01.22
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Pharmaceutical compositions comprising antibody-urease conjugates and substantially free of unconjugated urease are disclosed. These compositions are prepared by a method that does not require chromatographic purification. These pharmaceutical compositions have utility in the treatment of cancer by antibody-directed enzyme prodrug therapy wherein the urease converts endogenous urea into ammonia in situ to induce cytotoxicity.