CONJUGUES ANTICORPS-UREASE POUR DES FINS THERAPEUTIQUES

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专利权人:

HELIX BIOPHARMA CORPORATION

发明人:

CHAO, HEMAN,WONG, WAH YAU,TIAN, BAOMIN,GASPAR, KIMBERLY JAYNE,KUMAR, PRAVEEN

申请号：

CA2973538

公开号：

CA2973538A1

申请日:

2016.01.22

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

Pharmaceutical compositions comprising antibody-urease conjugates and substantially free of unconjugated urease are disclosed. These compositions are prepared by a method that does not require chromatographic purification. These pharmaceutical compositions have utility in the treatment of cancer by antibody-directed enzyme prodrug therapy wherein the urease converts endogenous urea into ammonia in situ to induce cytotoxicity.

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