Method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)prop-2-en-1-one

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专利权人:

Hanmi Pharm. Co.; Ltd.

发明人:

Bang, Keuk Chan,Jung, Jae Hyuk,Moon, Young Ho

申请号：

AU2014210494

公开号：

AU2014210494A1

申请日:

2014.01.27

申请国别(地区):

AU

年份:

2015

代理人:

摘要：

The present invention relates to a novel method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)prop-2-en-1-one in a simpler process as compared with conventional methods by allowing 4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-ol to react with an N-acyl piperidine derivative in an inert polar protic solvent in the presence of a base.

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