SCHRIMPF MICHAEL R,NERSESIAN DIANA L,SIPPY KEVIN B,JI JIANGUO,LI TAO,SCANIO MARC,SHI LEI,LEE CHIH-HUNG,BUNNELLE WILLIAM H,ZHANG GEOFF G Z,BRACKEMEYER PAUL J,CHEN SHUANG,HENRY RODGER F
申请号：
NZ61813407
公开号：
NZ618134A
申请日:
2007.11.06
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed herein are the azaadamantane derivative compounds: (4s)-4-(6-phenylpyridazin-3-yloxy)-1-azatricyclo[3.3.1.13,7]decane； (4r)-4-(6-phenylpyridazin-3-yloxy)-1-azatricyclo[3.3.1.13,7]decane； (4s)-4-(5-phenylpyridin-2-yloxy)-1-azatricyclo[3.3.1.13,7]decane； (4r)-4-(5-phenylpyridin-2-yloxy)-1-azatricyclo[3.3.1.13,7]decane； 5-[2-(1-azatricyclo[3.3.1.13,7]decan-(4s)-yloxy)thiazol-5-yl]-indolin-2-one； 5-[2-(1-azatricyclo[3.3.1.13,7]decan-1-oxide-(4s)-yloxy)thiazol-5-yl]-indolin-2-one； (4s)-4-(5-phenoxy-1,3,4-thiadiazol-2-yloxy)-1-azatricyclo[3.3.1.13,7]decane； (4s)-N-(6-phenylpyridin-3-yl)-1-azatricyclo[3.3.1.13,7]decan-4-amine； (4s)-N-[5-(3-methylphenyl)-pyridin-3-yl]-1-azatricyclo[3.3.1.13,7]decan-4-amine； (4s)-N-[5-(3-chlorophenyl)-pyridin-3-yl]-1-azatricyclo[3.3.1.13,7]decan-4-amine； (4s)-4 N-[5-(3-chlorophenylphen-3-yl)-pyridin-3-yl]-1-azatricyclo[3.3.1.13,7]decan-4-amine； (4s)-4-{ [5-(4-chlorophenyl)pyridin-3-yl]oxy} -1-azatricyclo[3.3.1.13,7]decane； 5-{ 5-[(4s)-1-azatricyclo[3.3.1.13,7]dec-4-yloxy]pyridin-2-yl} -1,3-dihydro-2H-indol-2-one； 6-[(4s)-1-azatricyclo[3.3.1.13,7]dec-4-yloxy]-N-pyridin-4-ylpyridine-2-carboxamide； (4r)-4-[(6-phenylpyrazin-2-yl)oxy]-1-azatricyclo[3.3.1.13,7]decane； 2-[(4s)-1-azatricyclo[3.3.1.13,7]dec-4-yloxy]-N-pyridin-4-yl-1,3-thiazole-4-carboxamide； 2-[(4s)-1-azatricyclo[3.3.1.13,7]dec-4-yloxy]-N-(4-chlorophenyl)-1,3-oxazole-4-carboxamide； 2-[(4s)-1-azatricyclo[3.3.1.13,7]dec-4-yloxy]-N-phenyl-1,3-oxazole-4-carboxamide； or (4s)-5-4-[2-(1-azatricyclo[3.3.1.13,7]decan-1-oxide-yloxy)thiazol-5-yl]-indolin-2-one. Also disclosed are compositions comprising the compounds and uses thereof as nicotinic acetylcholine receptor ligands, useful in the treatment of conditions or disorders such as attention deficit disorder, attention deficit hyperactivity disorder (ADHD), Alzheimer&rsquo；s disease, mild cognitive impairment, schizophrenia, age-associated memory impairment (AAMI), senile dementia, AIDS dementia, Pick&rsquo；s disease, dementia ass
