PESZKE; Jerzy Przemysław;PESZKE, Jerzy Przemysław;SZYMANSKI, Zygmunt Jerzy
发明人:
PESZKE, Jerzy Przemysław,SZYMANSKI, Zygmunt Jerzy
申请号：
IBIB2015/059363
公开号：
WO2016/088093A1
申请日:
2015.12.04
申请国别(地区):
IB
年份:
2016
代理人:
摘要：
A propolis-silver formulation is characterized in that comprises an extract of propolis in ethanol at a weight ratio of 1: 1- 4: 1 devoiding of any waxy substances, and silver in a form of complex with polyethylene glycol (PEG) in an amount of 0.001-0.1% by weight, wherein silver is in a complex in amount of 10 ppm/lml (or 1 g of fluid) and polyethylene glycol (PEG) is present in a total amount of 20-50% by weight, lanolin in amount of 10-50% by weight, petrolatum and optionally oils preferably in amount of 1-20% by weight, relative to the total mass of formulation. A process for preparing a propolis- silver formulation is characterized in that the extract of propolis obtained by known method by washing propolis with ethanol or ethanol and water mixture or other polar compound, after separating any waxy substances, preferably by vacuum filtration, is cooled to temperature of crystallization of the wax, after separation of which preferably by filtration under pressure, the filtrate after evaporation is poured with water/ethanol/isopropanol mixture made preferably in a volume ratio of 65:20:15 at a weight amount of 3:1 - 5:1 relative to the extract, and then it is shaken for 6 -24 hours, filtered, cooled to temperature about 3 °C, and then the solution after separation of waxy substances, is re-evaporated to dryness and the residue is treated with ethanol at a weight ratio of 1: 1 - 4: 1 on a dry mass, and further the obtained solution in an amount of 1 - 60% relative to the mass of the final product, is mixed with hydrophobic medium preheated to temperature of 25 - 45 °C, comprising 10 to 50% by weight lanolin, petrolatum or optionally oils, and finally after its homogenization it is added of 0.001 - 0.1% silver in complex form with polyethylene glycol ( PEG).L'invention concerne une formulation d'argent et de propolis caractérisée en ce qu'elle comprend un extrait de propolis dans de l'éthanol selon un rapport en poids de 1/1-4/1, exempt de toute substance cireuse,
