Christopher R. McCurdy,Christophe Mesangeau,Rae Reiko Matsumoto,Jacques Henri Poupaert,Bonnie Ann Avery,Ahmed Hassan Amin Abdelazeem
申请号：
US12785217
公开号：
US08686008B2
申请日:
2010.05.21
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Compounds having the general formula II, III, or IVwherein R1 can be a radical of an optionally substituted C-4 to C-7 N-containing heterocycle or a radical of an optionally substituted cyclic or acyclic tertiary amine or isoindoline-1,3-dione: R2,3,4,5,6 can each independently be any one or combinations of the following moieties, cyano, nitro, acyl, alkyl, amido, azido, isothiocyanate, isocyanate, optionally substituted anilino, halogens, ethers, sulfonamides, thioacyl, nitro, aromatic, heterocyclic, olefinic, acetylene, deuterium, or tritium Y can be either CH, CH2, O, S, OCH2, N—R, N—Ar, C—R, C—Ar Z can be either H, O, S, S—R or NR. R groups can be either H, aryls, alkyls, or cycloalkyls “n” can be 1 to 5 carbons in length and stereoisomers, functional analogs, and pharmaceutically acceptable salts thereof and wherein the moiety bridging R1 and N can be a substituted alkylene, optionally substituted alkenylene or optionally substituted alkynylene and where the alkylene group can include an inserted C3-C5 cycloalkyl group, aromatic, and hetercocyclic group wherein X′ is halogen, or C1-C4 haloalyl wherein the Rx is a C1-C5 straight chain or branched chain alkyl or a C1-C4 straight chain or branched chain haloalkyl.
