Linghong Xie;John Emmerson Campbell;Philip Jones;Michael Charles Hewitt
发明人:
John Emmerson Campbell,Michael Charles Hewitt,Philip Jones,Linghong Xie
申请号：
US13700051
公开号：
US08969349B2
申请日:
2011.05.26
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Provided herein are compounds of formula A-L-B, and pharmaceutically acceptable salts and stereoisomers thereof, wherein A isR1 and R2 together with the carbon atoms to which they are attached form a 1,2-phenylene ring optionally substituted with one or more R11； L is —C(R6)2—C(R6)2—； B is a heteroaromatic group defined herein； and -A1-A2- , A3, R11 and R6 are defined herein. Also disclosed are methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.
