A reposable surgical clip applier includes a handle assembly, a shaft assembly releasably engagable with the handle assembly, and a clip cartridge assembly releasably engagable within the shaft assembly. When the reposable surgical clip applier is assembled, a proximal drive of the handle assembly is positioned proximally adjacent an inner drive of the shaft assembly such that movement of handle(s) of the handle assembly towards an approximated position actuates a jaw assembly of the shaft assembly. When the reposable surgical clip applier is assembled, a proximal pusher of the handle assembly is positioned proximally adjacent a distal pusher of the clip cartridge assembly such that movement of the handle(s) towards a spaced-apart position loads a distal-most surgical clip from the clip cartridge assembly into the jaw assembly.
