A reposable surgical clip applier includes a handle assembly, a shaft assemblyreleasably engagable with the handle assembly, and a clip cartridge assemblyreleasablyengagable within the shaft assembly. When the reposable surgical clip applieris assembled,a proximal drive of the handle assembly is positioned proximally adjacent aninner drive ofthe shaft assembly such that movement of handle(s) of the handle assemblytowards anapproximated position actuates a jaw assembly of the shaft assembly. When thereposablesurgical clip applier is assembled, a proximal pusher of the handle assemblyis positionedproximally adjacent a distal pusher of the clip cartridge assembly such thatmovement of thehandle(s) towards a spaced-apart position loads a distal-most surgical clipfrom the clipcartridge assembly into the jaw assembly.