N1-2-thiophene-2-ylethyl-N2-substituted biguanide derivate, preparation method thereof, and pharmaceutical composition containing the same as active ingredients
Sung Wuk Kim,Sung Soo Jun,Hyae Gyeong Cheon,Kwang Rok Kim,Sang Dal Rhee,Won Hoon Jung,Jong Cheol Lee
申请号：
US13123296
公开号：
US08648111B2
申请日:
2009.10.13
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention provides an N1-2-thiophen-2-ylethyl-N2-substituted biguanide derivative of formula (I) or a pharmaceutically acceptable salt thereof, a method for preparing same, and a pharmaceutical composition comprising same as an active ingredient. The inventive N1-2-thiophen-2-ylethyl-N2-substituted biguanide derivative exhibits improved blood glucose level- and lipid level-lowering effects even with a reduced dosage as compared to conventional drugs, and thus, it is useful for preventing or treating diabetes, metabolic syndromes such as insulin-independent diabetes, obesity and atherosclerosis, or a P53 gene defect-related cancer.
