A handle assembly for a clip applier includes a housing having a stationary handle and a barrel supported on the stationary handle. The barrel defines a lumen having a proximal portion and a distal portion configured to releasably receive an adapter assembly. A is operably coupled to the housing and includes a gripping portion and a stem portion movable distally through the proximal portion of the lumen in response to movement of the gripping portion towards the stationary handle. A plunger assembly is removably positionable within the proximal portion of the lumen and configured to operably couple the stem portion with an adapter assembly such that distal movement of the stem portion actuates the adapter assembly. A plug is removably engagable within the proximal end of the barrel to retain the stem portion, the plunger assembly, and the adapter assembly in operable relation relative to one another.
