<；p>；This invention comprises a composition comprising heat stable plant juice soluble plant proteins and a method of using the same for anti-pathogenesis effect. The said composition is standardized for a parameter of a property of the composition that is relatable to anti-pathogenesis property or to the content of the protein molecules having molecular weight of 26 kilo Daltons (kD) or less. The said anti-pathogenesis effect comprises an anti-microbial effect on living beings or as an Adiponectin agonist effect in mammals. The Adiponectin agonist effect in mammals comprises reducing the risk of one or more of a disorder selected from Type II diabetes, hyperlipidemia, atherosclerosis, hypertension, heart disease and obesity. The antimicrobial effect comprises reducing the risk of or treating the microbial infections in plants and animals, with or without synergistic interaction with other antimicrobial agents. This invention also comprises a plant material composition not containing heat stable proteins； wherein the composition is made by pulping the plant material, removing juice from the solid residue, heating juice to remove coagulable protein and non-protein matter as a coagulum, removing the coagulum and thereafter removing the heat stable proteins from the resulting composition, optionally treating the same to get a further composition comprises either non-protein hydrophilic plant juice solubles or non-protein lipophilic plant juice solubles or both together in same composition.<；/p>；
