A connector system having for joining tubes having an overmolded or bonded connector or manifold incorporating specialized features. The overmolded or bonded connector includes a tubular body, an input portion, at least one output portion, an internal fluid passageway, and at least one specialized feature such as a valve or sensor integrally molded or embedded therein. The connection system may be pre-sterilized, disposable and made for single-time usage in a closed fluid handling system.
