THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY;GLAXOSMITHKLINE BIOLOGICALS S.A.
发明人:
COHEN, JOSEPH D,MARCHAND, MARTINE,OCKENHOUSE, CHRISTIAN F,YADAVA, ANJALI
申请号：
NZ57423807
公开号：
NZ574238A
申请日:
2007.07.16
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is an immunogenic protein particle comprising the following monomers: a. a fusion protein comprising at least one repeat unit from the central repeat region of type I circumsporozoite (CS) protein of P.vivax, at least one repeat unit from the central repeat region of a type II CS protein of P.vivax and the S antigen of Hepatitis B (CSV-S), and b. a fusion protein comprising at least four repeat units of the central repeat region of CS protein of P. falciparum and S antigen of Hepatitis B (RTS), and c. optionally the S antigen from Hepatitis B. Also disclosed are compositions comprising the particle with an adjuvant.
