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Hepatitis B virus core protein and surface antigen protein and vaccine comprising the same
专利权人:
The Trustees of the University of Pennsylvania
发明人:
Weiner, David B.,Yan, Jian,Obeng-Adjei, Nyamekye
申请号:
AU2013318022
公开号:
AU2013318022B2
申请日:
2013.09.19
申请国别(地区):
AU
年份:
2017
代理人:
摘要:
Provided herein are nucleic acid sequences encoding hepatitis B virus (HBV) core proteins, surface antigen proteins, fragments and combinations thereof as well as genetic constructs/vectors and vaccines that express said protein sequences. These vaccines are able to induce an immune response peripherally and in the liver by recruiting both cellular and humoral agents. Also provided are methods for prophylactically and/or therapeutically immunizing individuals against HBV. The combination vaccine can also be used for particular design vaccines for particular levels of immune responses to HBV challenge.
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