Russell McMahen,Mark Tengler,Michael Sloane,Daniel Lockhart
申请号:
US12985340
公开号:
US08470375B1
申请日:
2011.01.05
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The invention relates to the formulation and quality control of liquid drug suspensions. In particular, the invention relates to methods of formulating liquid suspensions comprising drug-containing resin particles. The invention also relates to methods of confirming the acceptability of drug-containing resin particles for use in formulating liquid drug suspensions. The invention further relates to methods of formulating liquid suspensions in which drug-containing resin particles, the liquid suspension, or both are modified to achieve a desired in vitro dissolution profile. The invention also relates to a novel dissolution method and methods of predicting in vivo bioequivalence based on in vitro dissolution methods.