Russell McMahen,Mark Tengler,Michael Sloane,Daniel Lockhart
申请号：
US13904739
公开号：
US09057675B2
申请日:
2013.05.29
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention relates to the formulation and quality control of liquid drug suspensions. In particular, the invention relates to methods of formulating liquid suspensions comprising drug-containing resin particles. The invention also relates to methods of confirming the acceptability of drug-containing resin particles for use in formulating liquid drug suspensions. The invention further relates to methods of formulating liquid suspensions in which drug-containing resin particles, the liquid suspension, or both are modified to achieve a desired in vitro dissolution profile. The invention also relates to a novel dissolution method and methods of predicting in vivo bioequivalence based on in vitro dissolution methods.
