LEYSEN DIRK,DEFERT OLIVIER,BOLAND SANDRO,ALEN JO,BOURIN ARNAUD PIERRE JEAN
申请号：
NZ61630012
公开号：
NZ616300A
申请日:
2012.04.27
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Provided herein are new kinase inhibitors of Formula (I), wherein X is oxygen, -NH-, or a direct bond Y is -NH- or a direct bond n is an integer from 0 to 4 m is an integer from 0 to 4 Cy represents a bivalent radical consisting of a saturated (poly)cycle, including fused, bi-, spiro or bridged carbocycles and heterocycles in particular selected from the group consisting of: Formula (II), Ar is selected from the group comprising: Formula (III), R2 is hydrogen or methyl R8 is hydrogen, methyl, halogen, or alkynyl R1 is an aryl or heteroaryl more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, provided herein are new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, provided herein are methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases, ophthalmic diseases and Respiratory diseases.
