Jo Alen;Olivier Defert;Dirk Leysen;Sandro Boland;Arnaud Pierre Jean Bourin
发明人:
Dirk Leysen,Olivier Defert,Sandro Boland,Jo Alen,Arnaud Pierre Jean Bourin
申请号：
US14113941
公开号：
US09073905B2
申请日:
2012.04.27
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to new kinase inhibitors of Formula (I), wherein X is oxygen, —NH—, or a direct bond； Y is —NH— or a direct bond； n is an integer from 0 to 4； m is an integer from 0 to 4； Cy represents a bivalent radical consisting of a satured (poly)cycle, including fused, bi-, spiro or bridged carbocycles and heterocycles； in particular selected from the group consisting of: Formula (II), Ar is selected from the group comprising: Formula (III), R2 is hydrogen or methyl； R8 is hydrogen, methyl, halogen, or alkynyl； R1 is an aryl or heteroaryl more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases, ophthalmic diseases and Respiratory diseases.
