<；P>；PROBLEM TO BE SOLVED: To provide a safe antiallergic therapeutic agent containing Posterisan and Eksalb and being a medicine or a medicinal agent using killed organism of gram-negative bacterium or gram-positive bacterium alone or in mixed state, because it is thought that new treating method for autoimmune diseases can be provided when macrophage activation is safely induced and IL-12 or the like can be produced, though an autoimmune disease such as atopic dermatitis, asthma or cancer is intractable and a therapeutic medicine effective for these diseases scarcely exists, while posterisan is a therapeutic medicine for hemorrhoids in which infection-protecting action and wound healing action are clinically recognized and generally used and active ingredient of the agent is killed organism liquid of Escherichia coli and it is suggested that the active ingredient safely induces macrophage activation, though the treating mechanism is not clear. <；P>；SOLUTION: The agent having effect on atopic dermatitis model mouse is obtained by percutaneously using the suspension of Escherichia coli contained in posterisan. <；P>；COPYRIGHT: (C)2006,JPO&NCIPI
