Jay Nelson,Scott Hansen,Meaghan H. Hancock,Louis Picker,Klaus Frueh
申请号：
US15356627
公开号：
US20170143809A1
申请日:
2016.11.20
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Disclosed herein are recombinant CMV vectors comprising heterologous antigens and microRNA recognition elements to silence expression of CMV genes in the presence of microRNA derived from myeloid cells, an active UL128 protein and an active UL130 protein. Also disclosed are recombinant CMV vectors comprising heterologous antigens and microRNA recognition elements to silence expression of CMV genes in the presence of microRNA derived from myeloid cells, an inactive UL128 protein and an inactive UL130 protein. Also disclosed are methods of generating an unconventional immune response using these vectors. Such an immune response is characterized by generation of a CD8+ T cell response that is predominantly restricted by MHC-II.
