Nelson, Jay,Hansen, Scott,Hancock, Meaghan H.,Picker, Louis,Frueh, Klaus
申请号：
AU2016355468
公开号：
AU2016355468A1
申请日:
2016.11.20
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
Disclosed herein are recombinant CMV vectors comprising heterologous antigens and microRNA recognition elements to silence expression of CMV genes in the presence of microRNA derived from myeloid cells, an active UL128 protein and an active UL130 protein. Also disclosed are recombinant CMV vectors comprising heterologous antigens and microRNA recognition elements to silence expression of CMV genes in the presence of microRNA derived from myeloid cells, an inactive UL128 protein and an inactive UL130 protein. Also disclosed are methods of generating an unconventional immune response using these vectors. Such an immune response is characterized by generation of a CD8+ T cell response that is predominantly restricted by MHC-II.
