Bardroff, Michael,Carballido Herrera, Jose M.,Della Ducata, Daniela,Heusser, Christoph,Jaeger, Ute,Schwaerzler, Christoph
申请号：
AU2010230311
公开号：
AU2010230311B2
申请日:
2010.03.29
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention relates to antibodies that specifically bind to IL12Rβ1, the non-signal transducing chain of the heterodimeric IL12 receptor (together with IL12Rβ2 chain) as well as IL23 receptor (together with IL23Rα chain). The invention more specifically relates to specific antibodies that are IL12 and IL23 receptor antagonists capable of inhibiting IL12/IL18 induced IFN production of T cells and compositions and methods of use for said antibodies to treat pathological disorders that can be treated by inhibiting IFN production, such as rheumatoid arthritis, psoriasis or inflammatory bowel diseases or other autoimmune and inflammatory disorders.
