BARDROFF MICHAEL,CARBALLIDO HERRERA JOSE M,DELLA DUCATA DANIELA,HEUSSER CHRISTOPH,JAEGER UTE,SCHWAERZLER CHRISTOPH
申请号：
IN7380/DELNP/2011
公开号：
IN2011DN07380A
申请日:
2011.09.26
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
The present invention relates to antibodies that specifically bind to IL12Rß1, the non-signal transducing chain of the heterodimeric IL12 receptor (together with IL12Rß2 chain) as well as IL23 receptor (together with IL23Rα chain). The invention more specifically relates to specific antibodies that are IL12 and IL23 receptor antagonists capable of inhibiting IL12/IL18 induced IFNy production of T cells and compositions and methods of use for said antibodies to treat pathological disorders that can be treated by inhibiting IFNy production, such as rheumatoid arthritis, psoriasis or inflammatory bowel diseases or other autoimmune and inflammatory disorders.
