(R)-3-hydroxybutyrate esters for suppressing hunger (I) A method of suppressing hunger by lowering plasma ghrelin levels in a subject is described comprising administration of a compound selected from (i) (R)-3-hydroxybutyrate； (ii) an ester of (R)-3-hydroxybutyrate； and (iii) an oligomer of (R)-3-hydroxybutyrate, or a pharmaceutically acceptable salt or solvate thereof. Preferably the body weight of the subject is maintained or reduced. Preferably the method is for the treatment or prevention of obesity, pre-diabetes, diabetes, metabolic syndrome, cardiovascular disease, high blood pressure, or of a fatty liver disease, preferably selected from non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), alcoholic steatohepatitis (ASH) and non-alcoholic fatty disease (NAFL). Preferably the ester of (R)-3-hydroxybutyrate is a compound of formula (I), wherein R1 is a C1-C6alkyl group, which alkyl group carries up to five –OR2 substituents, wherein R2 represents hydrogen, or a C1-C6alkyl, or wherein –OR2 represents a (R)-3-hydroxybutyrate moiety； or R1 is a moiety derived from alcohol HOR1, wherein the alcohol is a sugar. Preferably the compound is (R)-3-hydroxybutyrate (R)-1,3-butanediol. The compound may be in the form of a nutritional composition further comprising a medium chain triglyceride of formula CH2Ra-CH2Rb-CH2Rc, where Ra, Rb and Rc are fatty acids having 5 to 12 carbon atoms.La présente invention concerne une méthode d'inhibition de la faim par réduction des niveaux plasmatiques de ghreline comprenant l'administration d'un composé à un organisme humain ou animal, le composé étant choisi parmi : (i) le (R)-3-hydroxybutyrate ； (ii) un ester de (R)-3-hydroxybutyrate ； et (iii) un oligomère de motifs (R)-3-hydroxybutyrate ； ou un sel ou solvate pharmaceutiquement acceptable de celui-ci. La présente invention concerne également une méthode d'administration d'un tel composé à une dose efficace dans la réduction de la faim afin qu'une perte o
