Arkansas Children's Hospital Research Institute, Inc.;BioVentures, LLC
发明人:
James, Laura P.,Hinson, Jack,Roberts, Dean,Gill, Pritmohinder S.
申请号：
AU2015218355
公开号：
AU2015218355B2
申请日:
2015.02.13
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
The present disclosure relates to acetaminophen protein adducts and methods of diagnosing acetaminophen toxicity using the acetaminophen protein adducts. The present disclosure provides acetaminophen (APAP)-protein adducts and methods of detecting acetaminophen-induced toxicity in a subject using APAP-protein adducts. One aspect of the present disclosure provides an APAP- prptein adduct for diagnosing acetaminophen-induced toxicity. According to the present disclosure, the inventors have identified proteins that are modified by N-acetyl-pbenzoquinoneimine (NAPQI) in subjects with acetaminophen-induced toxicity. Non-limiting examples of proteins modified by NAPQI include betaine-homocysteine S-methyltransferase 1, cytoplasmic aspartate aminotransferase, 1,4-alpha-glucan branching enzyme, formimidoyltransferase-cyclodeaminase, and dystrophin.
