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HYPERSULPHATED DISACCHARIDES FOR TREATMENT OF DISORDERS ASSOCIATED WITH ELASTASIS
专利权人:
ОПКО Хелс; Инк. (US)
发明人:
АХМЕД Тахир (US),ЭЙБРАХАМ Уильям (US)
申请号:
RU2013116520/15
公开号:
RU2013116520A
申请日:
2011.10.27
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A pharmaceutical composition suitable for delivery to the lungs of a patient in need of such treatment, comprising a compound of formula I and its pharmaceutically acceptable salts R, R, R, R, R and R are independently selected from the group consisting of H, SOH or POH, provided that at least two of R-R are selected from SOH or POH. 2. The composition according to claim 1, characterized in that at least three of R-R are selected from SOH or POH. The composition according to claim 1, characterized in that at least four of the R-R are selected from SOH or POH. The composition according to claim 1, characterized in that at least five of R-R are selected from SOH or POH. The composition according to claim 1, characterized in that R-R are selected from SOH or POH. A dry powder pharmaceutical composition containing (i) a compound of formula I and its pharmaceutically acceptable salts R, R, R, R, R and R are independently selected from the group consisting of H, SOH or POH, provided that at least two of R-R selected from SOH or POH. 7. A pharmaceutical composition suitable for nebulization comprising (i) a compound of formula II and pharmaceutically acceptable salts thereof, wherein R, R, R and R are independently selected from the group consisting of H, SOH or POH; R is selected from SOH or POH; and (ii) an agent for delivery. 8. A composition in the form of an aerosol, dry powder or spray composition according to claim 1, characterized in that the compound of formula I is selected from a compound containing the following R-R and its pharmaceutically acceptable salts. A method of treating or alleviating an elastase-related condition in an animal in need of such treatment, comprising administering (i) a pharmaceutically effective amount of a composition containing a compound of formula I and pharmaceutically acceptable salts thereof, wherein R-R is independently selected from SOH or POH or H, provided that at least two of R-R1. Фармацевтический состав, подходящий для д
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