This invention regards the dermal absorption formulation which makes that it prescribes to stability the anti- acknowledgment symptom medicine over the long period of time possible. From as for details, as for this invention, sticking on the skin, it is used, being the dermal absorption formulation of the anti- acknowledgment symptom medicine, is stuck to the skin, possessing with adhesion layer and the interlayer and medicine content layer at least from the side which in order either, medicine content layer, including with the anti- acknowledgment symptom remedy medicine and possess the amino group the high polymer and the polyatomic alcohol and the carboxylic acid ester above kind which at least or, the interlayer, is controlled to the skin side of the anti- acknowledgment symptom medicine makes the transmission which possible to be something which, adhesion layer, the said dermal absorption formulation on the skinIt makes sticking possible, it regards the dermal absorption formulation which features that it is something which possesses permeability at the same time vis-a-vis the anti- acknowledgment symptom medicine.本発明は、抗認知症薬物を長期間にわたり安定に投与することを可能とする経皮吸収製剤に関する。より詳しくは、本発明は、皮膚に貼付して用いられる、抗認知症薬物の経皮吸収製剤であって、皮膚に貼付される側から順に、粘着層と、中間膜と、薬物含有層とを少なくとも有してなり、薬物含有層が、抗認知症治療薬物と、アミノ基を有する高分子化合物と、多価アルコールと、一種以上のカルボン酸エステルとを少なくとも含んでなり、中間膜が、抗認知症薬物の皮膚側への制御された透過を可能とするものであり、粘着層が、該経皮吸収製剤を皮膚に貼付可能にし、かつ抗認知症薬物に対して透過性を有するものであることを特徴とする経皮吸収製剤に関する。
