It has been authoritatively noted that after 100 years of cancer research, the life expectancy in most cancers has only increased by about 3 months. New, effective treatments for cancer are badly needed. The present invention relates to methods to use high doses of Dehydroepiandrosterone, doses sufficient to inhibit tumor Glucose-6-Phosphate Dehydrogenase and thereby deplete tumor NADP(H) pools, with a reconstitution mixture that replenishes metabolites required by normal tissues, thereby avoiding side effects that would otherwise occur. The combination of High Dose Dehydroepiandrosterone and the reconstitution mixture is termed Naturasone™, and its use is described herein both as a replacement for prednisone, and as a standalone cancer medication.
