PROBLEM TO BE SOLVED: To provide a lipid metabolism-improving agent in which the effect that improves the disorder of lipid metabolism of an animal is high by the ingredient of a processed Brasenia schreberi.SOLUTION: Brasenia schreberi is processed and the lipid metabolism-improving agent is manufactured. The lipid metabolism-improving agent decreases the neutral fat value in blood. Moreover, the proportion of the small and dense LDL (sdLDL) that occupies in all LDL is especially decreased. Actually, the lipid metabolism-improving agent decreases the expression of the lipid metabolism related gene of a fatty acid synthesis system and a cholesterol synthesis system at an in vitro experiment. Moreover, the reduction of the molecular weight of LDL cholesterol is suppressed, and sdLDL can be reduced also in a human.COPYRIGHT: (C)2012,JPO&INPIT【課題】効果の高い脂質代謝改善剤を提供する。【解決手段】ジュンサイ(Brasenia schreberi)を加工して脂質代謝改善剤を製造する。この脂質代謝改善剤は、血中中性脂肪値を低下させる。また、特に全LDLに占めるsmall,dense LDL(sdLDL)の割合を低下させる。実際に、この脂質代謝改善剤は、in vitro実験にて、脂肪酸合成系及びコレステロール合成系の脂質代謝関連遺伝子の発現を低下させる。また、ヒトにおいても、LDLコレステロールの分子量の減少を抑え、sdLDLを少なくすることができる。【選択図】図6
