The present invention 2 to hold the acid motif phenyl-pyrimidine derivatives and in humans and other mammals, including thrombosis (thrombosis), platelet aggregation (platelet aggregation) and associated peripheral vascular (peripheral vascular), internal blood vessels (vascular visceral ), liver veins (hepatic vascular), new blood vessels (renal vascular), cardiovascular (cardiovascular) and cerebral blood vessels (cerebrovascular) disease or disorder in the treatment and / or prevention in the P2Y 12 receptor antagonists (receptor antagonist) as their use in the and relationships.본 발명은 포스폰산 모티프를 보유하는 2-페닐-피리미딘 유도체 및 인간과 다른 포유동물에서 혈전증(thrombosis)을 비롯한, 혈소판 응집(platelet aggregation)과 연관된 말초 혈관(peripheral vascular), 내장 혈관(visceral vascular), 간혈관(hepatic vascular), 신혈관(renal vascular), 심혈관(cardiovascular)과 뇌혈관(cerebrovascular) 질환이나 장애의 치료 및/또는 예방에서 P2Y12 수용체 길항물질(receptor antagonist)로서 이들의 용도에 관계한다.