Methods and devices are provided for managing fluid flow through a body part, such as all or portions of an organ or extremity. In general, fluid inflow and fluid outflow vessels to at least a portion of a body part can be managed such that blood flow characteristics can be changed while maintaining, reducing, or increasing pressure of the associated flow. In some embodiments, pressure can be controlled while all fluid in at least a portion of the inflow and outflow vessels flows in an opposite direction.
