DÉRIVÉS DE 3-CARBOXYPROPYL-AMINOTÉTRALINE ET COMPOSÉS ASSOCIÉS EN TANT QU'ANTAGONISTES DU RÉCEPTEURS MU-OPIOÏDE

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专利权人:

THERAVANCE; INC.

发明人:

申请号：

EP08859864.4

公开号：

EP2231585B1

申请日:

2008.12.10

申请国别(地区):

EP

年份:

2013

代理人:

摘要：

The invention provides 3-carboxypropyl-aminotetralin compounds of formula (I): wherein R1, R2, R3, R4, R5, and R6 are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.

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