SEAN G. TRAPP,MICHAEL LEADBETTER,DANIEL D. LONG,JOHN R. JACOBSEN,PRISCILLA VA DYKE,PIERRE-JEAN COLSON,MIROSLAV RAPTA,YING YU
申请号：
BRPI0821611
公开号：
BRPI0821611A2
申请日:
2008.12.10
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
The invention provides 3-carboxypropyl-aminotetralin compounds of formula (I): wherein R1, R2, R3, R4, R5, and R6 are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.
