YOON, SEONG JUN,JUN, SOO YOUN,KWON, AN SUNG,KANG, SANG HYEON,JEONG, YONG YEON,PARK, IN KYU,CHO, CHONG SU,KIM, YOU KYOUNG,KIM, WON JONG,NAMGUNG, RAN
申请号：
EP11860590
公开号：
EP2679247A4
申请日:
2011.03.08
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
The present invention relates to a magnetic resonance imaging (MRI) contrast agent coated with carboxylated mannan, particularly a carboxylated mannan coated superparamagnetic MRI contrast agent specifically targeting antigen presenting cells and having excellent in vivo stability, and a method for producing the same. The MRI contrast agent coated with carboxylated mannan of the present invention can provide excellent in vivo stability and biocompatibility owing to its high surface negative charge, and can be introduced specifically into antigen presenting cells owing to mannose of mannan, so as to visualize the antigen presenting cells and the tissue containing the antigen presenting cells in MRI.
