PROCESS FOR CHANGING THE CRYSTAL FORM OF MYCOPHENOLATE SODIUM SALT

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专利权人:

NOVARTIS AG;NOVARTIS PHARMA GMBH

发明人:

PFEFFER, SABINE,WIECKHUSEN, DIERK

申请号：

AT04703158

公开号：

AT546132T

申请日:

2004.01.19

申请国别(地区):

AT

年份:

2012

代理人:

摘要：

Process for modifying the crystal habit of an acicular drug crystal wherein the acicular drug substance is a mycophenolate sodium salt, comprising suspending said crystalline drug substance in a methanol/water solvent and subjecting said suspension to a temperature oscillation, wherein the crystal habit is modified in that the mean aspect ratio of the processed crystals is smaller than 10:1 and the bulk density is above 200 kg/m 3 .

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中国工程科技知识中心

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http://www.ckcest.cn/home/