Sposób modyfikacji pokroju krysztalów substancji leczniczej, krysztaly mykofenolanu sodu i ich zastosowanie oraz kompozycja farmaceutyczna

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专利权人:

NOVARTIS AG

发明人:

PFEFFER SABINE,WIECKHUSEN DIERK

申请号：

PL39338504

公开号：

PL213192B1

申请日:

2004.01.19

申请国别(地区):

PL

年份:

2013

代理人:

摘要：

Process for modifying the crystal habit of an acicular drug crystal wherein the acicular drug substance is a mycophenolate sodium salt, comprising suspending said crystalline drug substance in a methanol/water solvent and subjecting said suspension to a temperature oscillation, wherein the crystal habit is modified in that the mean aspect ratio of the processed crystals is smaller than 10:1 and the bulk density is above 200 kg/m 3 .

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/