Disclosed is a double strand RNA compound having the structure: 5'iB GCCAGAAUGUGGAACUCCU 3' (sense strand) 3' CGGUCUUACACCUUGAGGA 5' (antisense strand) Wherein each nucleotide is a ribonucleotide and each consecutive ribonucleotide is joined to the next ribonucleotide by a phosphodiester bond； And wherein the sense strand comprises an L-deoxycytidine at position 18, and an inverted abasic 5' cap, and the antisense strand comprises a 2'-O-Me sugar modified ribonucleotide at positions 2, 4, 6, 8, 11, 13, 15, 17 and 19. Further disclosed is the use of said compound in the preparation of a medicament for treating a patient suffering from an ocular disease, an ocular disorder, an ocular injury, a visual field loss, or for providing ocular neuroprotection.
