A pharmaceutical composition containing dipine drugs includes dipine substances themselves, polysorbate, polyethylene glycol (PEG) and other pharmaceutical acceptable excipients. The dipine drug is about 5% to 20% wt of the pharmaceutical composition. The weight ratio of polysorbate to dipine drug is about 0.2~2:1. The weight ratio of PEG to dipine drug is about 0.1~2:1. The present invention is directed to enhance the dissolution of dipine drugs。一種地平類藥學組成物,其包含地平類藥物、聚醇山梨酯、聚乙二醇及其他醫學上可接收之賦型劑。地平類藥物之重量比例約為5至20%。聚醇山梨酯:地平類藥物之重量比例約為0.2~2:1;聚乙二醇:地平類藥物之重量比例約為0.1~2:1。本發明可增加地平類藥物之溶離度。