The medicine formulation of the granulation condition which is improved, with manner and the device which in order to prepare the granulation which is used with the particular formulation are improved it is disclosed. That kind of manner although the granulation which designates the medicine formulation for the solid-state internal use as application is produced especially is useful, 5 amino salicylic acid (5 ASA) the granulation which is included is produced in addition although as a one for remedy of the inflammatory bowel disease, especially it is suited. The granulation, compared to the length distribution which forms peak sharply, therefore shows aspect ratio distribution, as a result, furthermore after treating, furthermore possesses sharper dissolved profile.改善された顆粒状の医薬製剤が、当該製剤で用いられる顆粒を調製するための改善された方法及び装置と共に開示される。そのような方法は、固体の経口投与用医薬製剤を用途とする顆粒を製造するのに特に有用であり、また炎症性腸疾患の治療用として5-アミノサリチル酸(5-ASA)を含む顆粒を製造するのに特に適する。顆粒は、よりシャープにピークをなす長さ分布、したがってアスペクト比分布を示し、その結果、さらに処理した後にさらによりシャープな溶解プロファイルを有する。
