[Technical Problem]To provide a medicine cassette and a medicine packing device having compact structures, and also having ability of dispensing medicine one at a time by a first rotating body and a second rotating body.[Solution to Problem]In the main body of the cassette, a cylindrical body 50 where medicine is accommodated, a first rotating body 51 placed at the underside of the cylindrical body 50 and being rotatable around a first rotating axis 17, and a second rotating body 52 placed at the outer periphery of the opening of the cylindrical body 50 and being rotatable around a second rotating axis 22 are provided. At least drive means 30 and 31 for rotating and driving the first rotating body 51 and the second rotating body 52 are provided in the extra space of the main body of the cassette 49.