Refers to a compound of formula I, where XC is s, o, NH, N - (alkyl of C1 - C6) is optionally substituted carbamoilo RC2, RC3 is optionally substituted Hydroxy RC5 is a cyclic Group optionally substituted RC6 is c1-c6 alkyl, optionally substituted RC7 is H, halogen, alkyl of C1 - C6 or To get out of it.Preferred compounds are: 6 - Ethyl N - [1 - (piperidin-4-yl hidroxiacetil) yl] - 1 - methyl - 4 - oxo - phenyl - 3 - 5 - (2,2,2-trifluoroethoxy) - 4,5-dihydro - 3.2 - 1H pyrrolo [c] pyridine - 2, 3 - ethoxy - carboxamide - 6 - ethyl 5 - (4-fluorophenyl) - N - [1 - (piperidin-4-yl hidroxiacetil) yl] - 1 - methyl - 4 - oxo 4,5-dihydro - 3.2 - 1H pyrrolo [c] pyridine - 2 - carbox Amide n - [1 - (hidroxiacetil) piperidin-4-yl] Il - 1.6 - dimethyl - 5 - (4-methylphenyl) - 3 - (4 - oxo - 2.22) - - trifluoroetoxi 4,5-dihydro - 1H pyrrolo [c] pyridine - 2 - 2 - carboxamide among others. These compounds are of SMO inhibitors useful in the treatment of cancerREFERIDA A UN COMPUESTO DE FORMULA I, DONDE Xc ES S, O, NH, N-(ALQUILO C1-C6) Rc2 ES CARBAMOILO OPCIONALMENTE SUSTITUIDO Rc3 ES HIDROXI OPCIONALMENTE SUSTITUIDO Rc5 ES UN GRUPO CICLICO OPCIONALMENTE SUSTITUIDO Rc6 ES ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO Rc7 ES H, HALOGENO, ALQUILO C1-C6 O UNA SAL DEL MISMO. SON COMPUESTOS PREFERIDOS: 6-ETIL-N-[1-(HIDROXIACETIL)PIPERIDIN-4-IL]-1-METIL-4-OXO-5-FENIL-3-(2,2,2-TRIFLUOROETOXI)-4,5-DIHIDRO-1H-PIRROLO[3,2-c]PIRIDINA-2-CARBOXAMIDA 3-ETOXI-6-ETIL-5-(4-FLUOROFENIL)-N-[1-(HIDROXIACETIL)PIPERIDIN-4-IL]-1-METIL-4-OXO-4,5-DIHIDRO-1H-PIRROLO[3,2-c]PIRIDINA-2-CARBOXAMIDA N-[1-(HIDROXIACETIL)PIPERIDIN-4-IL]-1,6-DIMETIL-5-(4-METILFENIL)-4-OXO-3-(2,2,2-TRIFLUOROETOXI)-4,5-DIHIDRO-1H-PIRROLO[3,2-c]PIRIDINA-2-CARBOXAMIDA ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE Smo UTILES EN EL TRATAMIENTO DE CANCER
