Methods and compositions to elicit multivalent immune responses against dominant and subdominant epitopes, expressed on cancer cells and tumor stroma

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专利权人:

MANNKIND CORPORATION

发明人:

BOT, ADRIAN,QIU, ZHIYONG

申请号：

NZ59190806

公开号：

NZ591908A

申请日:

2006.06.16

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

Disclosed is a nucleic acid construct encoding a polypeptide including one or more copies of CTL epitope PSMA288-297 (SEQ ID NO:6) and one or more copies of CTL epitope PRAME425- 433 (SEQ ID NO:5), or a cross-reactive analogue including 1-3 substitutions of one or both of said epitopes, wherein the polypeptide does not include a whole antigen, wherein the cross-reactive analogue of CTL epitope PSMA288-297 including 1-3 substitutions include a 1297V substitution, and wherein one or both epitopes are encoded within a liberation sequence.

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中国工程科技知识中心

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