KIM, JIN SUN,KIM, DAE JIN,LEE, SANG HYUN,JUNG, SUNG YOUB,KWON, SE CHANG
申请号：
SG11201503420Q
公开号：
SG11201503420QA
申请日:
2013.11.06
申请国别(地区):
SG
年份:
2015
代理人:
摘要：
Disclosed are a composition for preventing or treating diabetes, diabesity or diabetic complications, containing an oxyntomodulin analog as an active ingredient and a method for treating diabetes, diabesity or diabetic complications, including administering a pharmaceutically effective amount of an oxyntomodulin analog to a subject. The oxyntomodulin analog shows a greater activity to activate a GLP-1 receptor and a glucagon receptor, than native oxyntomodulin. The oxyntomodulin analog induces an expansion of beta-cells and increases insulin secretion, thereby reducing blood glucose levels that were increased due to a high-calorie and high-fat diet. The oxyntomodulin analog induces decreases in a body weight and appetite to improve insulin sensitivity and is useful in maintaining normal blood glucose levels.
