HANMI PHARM. CO.LTD;KIM JIN-SUN;JUNG SUNG YOUB;KWON SE CHANG;KIM DAE JIN;LEE SANG HYUN
发明人:
申请号：
IL23863115
公开号：
IL238631D0
申请日:
2015.05.04
申请国别(地区):
IL
年份:
2015
代理人:
摘要：
Disclosed are a composition for preventing or treating diabetes, diabesity or diabetic complications, containing an oxyntomodulin analog as an active ingredient and a method for treating diabetes, diabesity or diabetic complications, including administering a pharmaceutically effective amount of an oxyntomodulin analog to a subject. The oxyntomodulin analog shows a greater activity to activate a GLP-1 receptor and a glucagon receptor, than native oxyntomodulin. The oxyntomodulin analog induces an expansion of beta-cells and increases insulin secretion, thereby reducing blood glucose levels that were increased due to a high-calorie and high-fat diet. The oxyntomodulin analog induces decreases in a body weight and appetite to improve insulin sensitivity and is useful in maintaining normal blood glucose levels.
