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PHARMACEUTICAL COMPOUNDS
专利权人:
REVIRAL LIMITED
发明人:
Stuart George Cockerill,James Good
申请号:
US16631530
公开号:
US20200172515A1
申请日:
2018.07.20
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Benzimidazole derivatives of formula (I): wherein: R1 is —;(CH2)m-R4 or R2 is halo, —;(CH2)m—;NH2 or —;(CH2)n—;C(═;NH)—;NH2; R3 is H or F; R4 is —;NH—;(CH2)2—;(NH)r—;R5, —;NH—;(CHR5R6) or a group of the following formula (A): (A) W is —;(CH2)m—;, —;CH2—;O—;CH2—;, —;CH2—;S—;CH2—;, —;(CH2)r—;S(O)2—;CH2—; or —;(CH2)r—;NR5—;CH2—;; m is an integer of 1 to 3; n is 1 or 2; p is 1 and V is CH; or p is O and V is N; q is 0 or 1; r is 0 or 1; R5 is H, —;SO2Me, —;SO2Et, —;SO2CF3, —;COMe, —;CONMe2, —;CONH2 or —;CH2CH2SO2Me; R6 is H or C1-C6 alkyl; and R7 is —;SO2Me, —;SO2Et, —;SO2CF3, —;COMe, —;CONMe2, —;CONH2 or —;CH2CH2SO2Me; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.
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